Spermidine (as Spermidine Trihydrochloride)
A high-purity, laboratory-refined polyamine salt designed to trigger systemic autophagy—the body's innate cellular recycling process—to promote cellular renewal and cognitive longevity.
Cellular Recycling & Renewal
Spermidine acts as a potent mimetic of caloric restriction, triggering "autophagy." This vital process allows cells to identify, break down, and recycle damaged proteins and dysfunctional organelles, effectively "cleaning" the cell from the inside out to maintain peak performance.
Cardiovascular Resilience
Research indicates that Spermidine supports heart health by improving mitochondrial function in cardiomyocytes and promoting the structural integrity of blood vessels. It helps maintain healthy blood pressure levels and overall circulatory efficiency.
Synaptic Plasticity
Spermidine is crucial for brain health. By facilitating the clearance of amyloid-beta plaques and supporting synaptic plasticity, it aids in preserving memory function and protecting the nervous system against age-related cognitive decline.
References
Eisenberg, T., et al. (2016). "Cardioprotection and lifespan extension by the natural polyamine spermidine." Nature Medicine, 22(12), 1428-1438.
Wirth, M., et al. (2018). "Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)." Alzheimer's & Dementia, 14(7), P1101.
Soda, K., et al. (2021). "Spermidine-Rich Diet Mechanism and Cardiovascular Health." Frontiers in Nutrition, 8, 715316.