Nicotinamide Riboside (NR)
A clinically validated NAD+ precursor and a next-generation vitamin B3 derivative, specifically engineered to optimize cellular bioenergetics and facilitate comprehensive DNA repair pathways.
Molecular NAD+ Optimization
NR is a high-efficiency precursor to Nicotinamide Adenine Dinucleotide (NAD+). Unlike conventional B3, NR bypasses rate-limiting enzymes (NAMPT) to rapidly restore NAD+ levels, which naturally decline by up to 50% between the ages of 40 and 60.
Mitochondrial Biogenesis
By elevating NAD+ pools, NR facilitates the communication between the nucleus and mitochondria. It activates sirtuins (SIRT1 & SIRT3), improving mitochondrial efficiency and reducing oxidative stress at the cellular level.
DNA Repair & Longevity
NAD+ is the essential substrate for PARP enzymes, which are responsible for detecting and repairing damaged DNA strands. NR supplementation ensures these "molecular guardians" have the fuel required to maintain chromosomal stability.
References
Martens, C. R., et al. (2018). "Chronic supplementation with nicotinamide riboside is well-tolerated and elevates nicotinamide adenine dinucleotide in healthy middle-aged and older adults." Nature Communications, 9(1), 1286.
Conze, D., et al. (2019). "Safety and Metabolism of NRCL (NIAGEN) in a 8-Week Clinical Trial in Healthy Overweight Adults." Scientific Reports, 9(1), 1290.
Braidy, N., et al. (2019). "Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases." Frontiers in Aging Neuroscience, 11, 257.