Nicotinamide Mononucleotide (NMN)

A direct-acting NAD+ intermediate designed for rapid cellular uptake, facilitating systemic NAD+ saturation and optimizing age-related metabolic decline.

PURITY: 99.8% Certified

TYPE: NAD+ Precursor

THE SCIENCE

Direct NAD+ Synthesis

Unlike other precursors, NMN is the immediate precursor to NAD+ in the salvage pathway. Its molecular structure allows for rapid enzymatic conversion into NAD+, providing a more direct route to elevating cellular coenzyme levels.

Vascular Rejuvenation

Clinical studies suggest that NMN supplementation supports vascular endothelial function, promotes healthy blood flow, and enhances muscle insulin sensitivity, which are critical components of cardiovascular and metabolic longevity.

Chromosomal Integrity

NMN provides the necessary substrate for PARPs (Poly ADP-Ribose Polymerases). These enzymes are essential for repairing single-strand DNA breaks and maintaining the structural integrity of the genome against environmental stressors.

References

Mills, K. F., et al. (2016). "Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice." Cell Metabolism, 24(6), 795-806.

Irie, J., et al. (2020). "Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men." Endocrine Journal, 67(2), 153-160.

Yoshino, M., et al. (2021). "Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women." Science, 372(6547), 1244-1251.

Yi, L., et al. (2023). "The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial." GeroScience, 45, 29-43.